C0494
Cambinol
≥97% (HPLC), white, powder
Synonym(s):
5-(2-Hydroxynaphthalen-1-ylmethyl)-6-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one, 5-[(2-hydroxy-1-naphthyl)methyl]-2-mercapto-6-phenyl-4(3H)-Pyrimidinone, NSC-1125476, Tetrahydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-Pyrimidinone
About This Item
Recommended Products
Quality Level
Assay
≥97% (HPLC)
form
powder
color
white
solubility
DMSO: ≥10 mg/mL
storage temp.
room temp
SMILES string
Oc1ccc2ccccc2c1CC3=C(NC(=S)NC3=O)c4ccccc4
InChI
1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
InChI key
RVNSQVIUFZVNAU-UHFFFAOYSA-N
Application
- as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formation
- as a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cells
- as a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death
Biochem/physiol Actions
Features and Benefits
related product
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
C0494-BULK:
C0494-25MG:
C0494-VAR:
C0494-5MG:
Certificates of Analysis (COA)
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Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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