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Safety Information

B6060

Sigma-Aldrich

BVT.948

≥98% (HPLC), solid

Synonym(s):

4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

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About This Item

Empirical Formula (Hill Notation):
C14H11NO3
CAS Number:
39674-97-0
Molecular Weight:
241.24
MDL number:
MFCD00616487
UNSPSC Code:
12352200
PubChem Substance ID:
24724422
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

storage condition

desiccated
protect from light
under inert gas

color

red

solubility

DMSO: 18 mg/mL
H2O: insoluble

storage temp.

−20°C

SMILES string

CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12

InChI

1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3

InChI key

BAQXWJQSUXZVIP-UHFFFAOYSA-N

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B6060-5MG:
B6060-VAR:
B6060-BULK:
B6060-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tomasz Warzecha et al.
The plant pathology journal, 35(2), 112-124 (2019-04-23)
Barley worldwide is affected seriously by Fusarium seedling blight (FSB) and Fusarium head blight (FHB) diseases caused by the Fusarium species. The objective of this study was to facilitate the resistance of hulled and hull-less barley at different growth stages

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