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AC-0352A

Sigma-Aldrich

Claudin-4 (EP417) Rabbit Monoclonal Primary Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

antibody form

Ig fraction of antiserum

clone

monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200

shipped in

wet ice

storage temp.

2-8°C

visualization

(membrane)

General description

Claudin-4 is one of twenty-seven integral membrane tight junction proteins and specializes in paracellular sodium transport. Although claudin proteins are primarily known for their cell adhesion function, Claudin-4 binds to zonula occludens proteins and interacts with numerous signaling pathways. Claudin-4 is detectable in low amounts in the normal tissues of the lung, kidney, breast, prostate, bladder and gastrointestinal tract. It is a highly specific and sensitive membranous marker for most epithelial neoplasms. Absence of expression in normal mesothelium and mesothelioma provides utility in the differential diagnosis between carcinoma from mesothelioma with 99% specificity. In breast tumors, claudin-4 levels are significantly higher in ER-negative and high grade tumors when compared to ER-positive and low grade tumors. High levels of Claudin-4 expression are associated with later stages of progression and reduced patient survival for most types of epithelial neoplasms. Conversely, its expression is downregulated in gastric and high-grade bladder cancers, and is significantly lower in lymph node metastasis and esophageal tumors with distant metastasis. Low Claudin-4 expression is associated with a poor prognosis in esophageal squamous cell carcinoma.

Quality


IVD
IVD
IVD
RUO

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1%BSA and &< 0.1% Sodium Azide

Other Notes

For a copy of the IFU and CofA contact IVDorder@ABCAM.com

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AC-0352A:

Certificates of Analysis (COA)

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