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Key Documents

Safety Information

A9522

Sigma-Aldrich

Anti-Antithrombin III antibody produced in rabbit

fractionated antiserum, lyophilized powder

Synonym(s):

Anti-AT3

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About This Item

MDL number:
MFCD00162398
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

packaging

vial of 2 mL lyophilized antiserum

technique(s)

indirect ELISA: 1:25,000

UniProt accession no.

P01008

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... SERPINC1(462)

General description

Antithrombin III (ATIII) is a small glycoprotein produced by the liver that functions as a serine protease inhibitor to block coagulation.
Antithrombin III is a 58kDa glycoprotein synthesized in the liver. It has two domains, a heparin-binding domain and target protease binding domain.

Immunogen

human antithrombin III

Application

Anti-Antithrombin III antibody has been used in western blotting and antigenic assay.

Biochem/physiol Actions

Antithrombin III is a serine protease inhibitor which affects many intrinsic and extrinsic blood coagulation pathways. It inactivates the function of thrombin and factor X in blood. Severe sepsis is caused due to lack of antithrombin III.

Physical form

Lyophilized from 0.01 M phosphate buffered saline, pH 7.2

Reconstitution

Reconstitute with 2 mL deionized water.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A9522-1VL-PW:
A9522-VAR:
A9522-BULK:
A9522-1VL:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Defects of splicing in antithrombin deficiency
de la Morena-Barrio M E, et al.
Research and practice in thrombosis and haemostasis, 1(2), 216-222 (2017)
Mara Toderici et al.
PloS one, 11(3), e0152159-e0152159 (2016-03-24)
Antithrombin is a crucial anticoagulant serpin whose even moderate deficiency significantly increases the risk of thrombosis. Most cases with antithrombin deficiency carried genetic defects affecting exons or flanking regions of SERPINC1.We aimed to identify regulatory mutations inSERPINC1 through sequencing the
Antithrombin III in patients with severe sepsis
Eisele B, et al.
Intensive Care Medicine, 24(7), 663-672 (1998)
María Eugenia de la Morena-Barrio et al.
Frontiers in cardiovascular medicine, 9, 887664-887664 (2022-08-09)
Aortic valve replacement is the gold standard treatment for severe symptomatic aortic stenosis, but thrombosis of bioprosthetic valves (PVT) remains a concern. To analyze the factors involved in the contact pathway during aortic valve replacement and to assess their impact
Carlos Bravo-Pérez et al.
JCI insight, 7(19) (2022-10-11)
Antithrombin, a major endogenous anticoagulant, is a serine protease inhibitor (serpin). We characterized the biological and clinical impact of variants involving C-terminal antithrombin. We performed comprehensive molecular, cellular, and clinical characterization of patients with C-terminal antithrombin variants from a cohort
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