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A5686

Sigma-Aldrich

Arg-Gly-Glu-Ser acetate salt

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C16H29N7O8
CAS Number:
159002-32-1
Molecular Weight:
447.44
MDL number:
MFCD00133106
UNSPSC Code:
12352202
PubChem Substance ID:
329770831
NACRES:
NA.32

biological source

synthetic (organic)

Assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O

InChI

1S/C16H29N7O8.C2H4O2/c17-8(2-1-5-20-16(18)19)13(28)21-6-11(25)22-9(3-4-12(26)27)14(29)23-10(7-24)15(30)31;1-2(3)4/h8-10,24H,1-7,17H2,(H,21,28)(H,22,25)(H,23,29)(H,26,27)(H,30,31)(H4,18,19,20);1H3,(H,3,4)/t8-,9-,10-;/m0./s1

InChI key

SALKOFBHHIHLSW-PUBMXKGKSA-N

Gene Information

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

Amino Acid Sequence

Arg-Gly-Glu-Ser

Application

Arg-Gly-Glu-Ser acetate salt has been used:
  • as an integrin blocking peptide to study its effects on ciliary neurotrophic factor (CNTF) regulation in astroglioma cells
  • as a control peptide to study its effects on the binding of patient IgG to integrin αvβ6
  • as an integrin inhibitor peptide to study its effects on cell adhesion in Capsaspora owczarzaki cells

Biochem/physiol Actions

Arg-Gly-Glu-Ser peptide acts as an integrin-blocking peptide.
Inhibitor of platelet aggregation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A5686-5MG:
A5686-10MG:
A5686-VAR:
A5686-2MG:
A5686-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Gartner, T.K., et al.
Blood, 66, 305a-305a (1985)
Changsuk Moon et al.
Respiratory research, 10, 18-18 (2009-03-11)
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser (RGDS) peptide on key inflammatory responses to intratracheal (i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled mitogen-activated protein
Helena Parra-Acero et al.
Current biology : CB, 30(21), 4270-4275 (2020-08-29)
In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in animals. They are heterodimeric transmembrane proteins that
Jose V Moyano et al.
Molecular biology of the cell, 21(21), 3654-3668 (2010-09-17)
Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in facilitating recovery of epithelia from injury. We have shown that expression of LM-332 is up-regulated during renal epithelial regeneration after
Naeem A Ali et al.
PloS one, 3(4), e1914-e1914 (2008-04-09)
Latency Associated Peptide (LAP) binds TGF-beta1, forming a latent complex. Currently, LAP is presumed to function only as a sequestering agent for active TGF-beta1. Previous work shows that LAP can induce epithelial cell migration, but effects on leukocytes have not

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