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Safety Information

A5597

Sigma-Aldrich

Xylene Substitute

greener alternative

Synonym(s):

for microscopy

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About This Item

EC Number:
265-068-8
UNSPSC Code:
12171500
NACRES:
NA.47

form

solution

greener alternative product characteristics

Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

density

0.723 g/cm3

application(s)

hematology
histology

greener alternative category

, Aligned

storage temp.

2-8°C

General description

Compatible with all tissue processors. May not be compatible with all permanent mounting media.

Application

Xylene Substitute has been used to dewax or de-paraffinize the specimen sections after the staining process.We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has Inherently Safer Chemistry, compared to the standard use of formalin for tissue processing. For more information see www.sigmaaldrich.com/catalog/papers/19608083.

Pictograms

FlameHealth hazard
GHS02,GHS08

Signal Word

Danger

Hazard Statements

H225,H304

Hazard Classifications

Asp. Tox. 1 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

63.0 °F - closed cup

Flash Point(C)

17.2 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

A5597-1GAL:4548173984452
A5597-VAR:
A5597-BULK:
A5597-1GAL-H:
A5597-4X1GAL-PW:
A5597-1GAL-CH:
A5597-1GAL-PW:
A5597-4X1GAL:
A5597-4X1GAL-CH:
A5597-4X1GAL-H:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK6903
SLCJ4862
SLCH4914
SLCF3815
SLCC9528

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Jiaming Guo et al.
Scientific reports, 9(1), 14578-14578 (2019-10-12)
Analysis of three-dimensional biological samples is critical to understanding tissue function and the mechanisms of disease. Many chronic conditions, like neurodegenerative diseases and cancers, correlate with complex tissue changes that are difficult to explore using two-dimensional histology. While three-dimensional techniques
Jiaming Guo et al.
Biomedical optics express, 11(1), 99-108 (2020-02-06)
Immunohistochemical techniques, such as immunofluorescence (IF) staining, enable microscopic imaging of local protein expression within tissue samples. Molecular profiling enabled by IF is critical to understanding pathogenesis and is often involved in complex diagnoses. A recent innovation, known as microscopy
René J Buesa et al.
Annals of diagnostic pathology, 13(4), 246-256 (2009-07-18)
After the hazardous effects of xylene became indisputable in the 1970s, many potential substitutes became available, some with as many if not more hazards. This article discusses the inadequacy of 5 vegetable oils as substitutes, as well as the characteristics
M L Alves da Silva et al.
Journal of tissue engineering and regenerative medicine, 9(6), 714-723 (2013-10-25)
Paracrine signalling from chondrocytes has been reported to increase the synthesis and expression of cartilage extracellular matrix (ECM) by stem cells. The use of conditioned medium obtained from chondrocytes for stimulating stem cells chondrogenic differentiation may be a very interesting

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