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Key Documents

Safety Information

A1472

Sigma-Aldrich

MCA-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676-DNP-Lys-Arg-Arg-NH2

≥90% (HPLC)

Synonym(s):

7-Methoxycoumarin-4-acetyl-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 667-676(2,4-dinitrophenyl)Lys-Arg-Arg amide

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About This Item

Empirical Formula (Hill Notation):
C86H125N27O29
Molecular Weight:
2001.08
MDL number:
MFCD03454237
UNSPSC Code:
12352202
NACRES:
NA.32

Quality Level

100

Assay

≥90% (HPLC)

form

powder

UniProt accession no.

P05067

storage temp.

−20°C

Gene Information

human ... APP(351)

Amino Acid Sequence

MCA-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-DNP-Lys-Arg-Arg-NH2

Application

7-Methoxycoumarin-4-acetyl-[Asn⁶⁷⁰,Leu⁶⁷¹]-Amyloid β has been used as a fluorogenic substrate to measure β-secretase activity.

Biochem/physiol Actions

Fluorescent peptide substrate containing the ′Swedish′ Lys-Met/Asn-Leu mutation of the amyloid presursor protein (APP) β-secretase cleavage site. May be used for assaying β-secretase-like activity of thimet oligopeptidase (TOP), EC 3.4.24.15.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A1472-1MG:
A1472-VAR:
A1472-500UG-KC:
A1472-500UG:
A1472-1MG-PW:
A1472-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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