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94258

Sigma-Aldrich

Eriodictyol

≥95.0% (HPLC)

Synonym(s):

3′,4′,5,7-Tetrahydroxyflavanone

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About This Item

Empirical Formula (Hill Notation):
C15H12O6
CAS Number:
4049-38-1
Molecular Weight:
288.25
MDL number:
MFCD00017312
UNSPSC Code:
12352205
PubChem Substance ID:
329770317
NACRES:
NA.25

Quality Level

100

Assay

≥95.0% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

O=C1C2=C(O)C=C(O)C=C2OC(C3=CC=C(O)C(O)=C3)C1

InChI

1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2

InChI key

SBHXYTNGIZCORC-UHFFFAOYSA-N

Related Categories

General description

Eriodictyolis a bitter-masking dietary flavonoid primarily extracted from yerba Santa Clause (Eriodictyon californicum) and Dracocephalum rupestre, but also present in many other citrus fruits, medicinal plants, and vegetables.

Application

Eriodictyolmay has been used to study its mechanism on IgE/Ag-induced type I hypersensitivity inhibition at the level of mast cell degranulation and ceramide kinase activity. It may also be used to understand its potential antidiabetic activity and its neuroprotective activity via activation of the Nrf2/ARE signaling pathway.

Biochem/physiol Actions

Eriodictyolis absorbed in the body slowly and can be found in plasma and urine as homoeriodictyol, a conjugated form. It has many pharmacological properties such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-obesity, neuroprotective, cardioprotective, and hepatoprotective.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

For this product we use the non-stereospecific CAS number. It is expected that the natural enantiomer is predominant, however the substance is prone to racemization in solution. The product is therefore not specified stereospecifically and is only recommended to be used for non-stereospecific analysis.

Storage Class Code

11 - Combustible Solids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

94258-5MG:
94258-VAR:
94258-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Behavioural brain research, 312, 321-332 (2016-06-30)
Cerebral ischemia is a common disease and one of the most common causes of death and disability worldwide. The lack of glucose and oxygen in neuronal tissue leads to a series of inflammatory events, culminating in neuronal death. Eriodictyol is
Minpei Kuroda et al.
Natural product communications, 7(4), 471-474 (2012-05-12)
MeOH extracts of 37 herbs were tested in screening experiments for rat intestinal alpha-glucosidase. The MeOH extract of the aerial parts of Scutellaria lateriflora L. (Lamiaceae) significantly inhibited sucrase and maltase activities, using sucrose and maltase as the substrates. Enzyme
Ángel Amesty et al.
Journal of natural products, 74(5), 1061-1065 (2011-04-21)
Three new benzodihydrofurans (1-3) and seven known aromatic compounds (4-10) were isolated from the roots of Cyperus teneriffae. Vibrational circular dichroism spectroscopy was used to define the absolute configuration of 1.
Zirong Deng et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 6681352-6681352 (2021-01-09)
Eriodictyol is a flavonoid that belongs to a subclass of flavanones and is widespread in citrus fruits, vegetables, and medicinally important plants. Eriodictyol has been anticipated to explain the method of its activity via multiple cellular signaling cascades. Eriodictyol is
Anowarul Islam et al.
Archives of pharmacal research, 43(6), 582-592 (2020-07-01)
Eriodictyol is a flavonoid in the flavanones subclass. It is abundantly present in a wide range of medicinal plants, citrus fruits, and vegetables that are considered to have potential health importance. Having the considerable medicinal properties, eriodictyol has been predicted
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