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62966

Sigma-Aldrich

L-α-Lysophosphatidylinositol sodium salt from soybean

≥98.0% (TLC)

Synonym(s):

1-Acyl-sn-glycero-3-phospho-(1-D-myo-inositol)

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About This Item

MDL number:
MFCD00131447
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

soybean

Assay

≥98.0% (TLC)

form

powder

impurities

primarily palmitic acid
 stearic acid

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

Biochem/physiol Actions

Lysophosphatidylinositol, an endogenous phospholipid, is a novel ligand for the orphan G protein-coupled receptor 55 (GPR55) . Lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT (nuclear factor of activated T cells) activation in human embryonic kidney 293 cells .

Preparation Note

by phospholipase A2-treatment of 3-sn-phosphatidylinositol

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

62966-5MG:
62966-BULK:
62966-VAR:
62966-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lysophosphatidylcholine United States Pharmacopeia (USP) Reference Standard

USP

1372050

Lysophosphatidylcholine

Christopher M Henstridge et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(1), 183-193 (2008-09-02)
The endogenous phospholipid l-alpha-lysophosphatidylinositol (LPI) was recently identified as a novel ligand for the orphan G protein-coupled receptor 55 (GPR55). In this study we define the downstream signaling pathways activated by LPI in a human embryonic kidney (HEK) 293 cell
Saori Oka et al.
Biochemical and biophysical research communications, 362(4), 928-934 (2007-09-04)
GPR55 is an orphan G protein-coupled receptor. In this study, we explored a possible endogenous ligand for GPR55 using HEK293 cells which expressed GPR55. We found that lysophosphatidylinositol induced rapid phosphorylation of the extracellular signal-regulated kinase in transiently or stably

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