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Key Documents

Safety Information

61327

Sigma-Aldrich

Lactoferrin from human milk

iron-saturated, ≥85% (GE)

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About This Item

CAS Number:
936541-36-5
MDL number:
MFCD00164307
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

human milk

Assay

≥85% (GE)

form

solid

quality

iron-saturated

mol wt

82.4 kDa

concentration

≥0.15 % (w/w) Fe

solubility

0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown

UniProt accession no.

P02788

storage temp.

2-8°C

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

Gene Information

human ... LTF(4057)

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Application

Lactoferrin was used for development of lactoferrin immunosensor.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

61327-50MG-F:
61327-VAR-F:
61327-10MG-F:
61327-BULK-F:

Certificates of Analysis (COA)

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Luigi Campanella et al.
Journal of pharmaceutical and biomedical analysis, 53(2), 186-193 (2010-04-17)
The last year we fabricated some new immunosensors for the analysis of lactoferrin protein. In the present research the immunological and analytical characteristics of the immunosensor method have been extensively investigated. The study was therefore extended to cover the ability
Gregory T Spear et al.
PloS one, 6(5), e19560-e19560 (2011-05-17)
More than one million new cases of sexually transmitted diseases (STDs) occur each day. The immune responses and inflammation induced by STDs and other frequent non-STD microbial colonizations (i.e. Candida and bacterial vaginosis) can have serious pathologic consequences in women

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