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52423

Sigma-Aldrich

Dextran sulfate sodium salt from Leuconostoc spp.

low sulfate content, Mr ~40,000

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About This Item

CAS Number:
9011-18-1
MDL number:
MFCD00081551
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

(Leuconostoc spp)

Quality Level

100

form

powder

quality

low sulfate content

mol wt

Mr ~40,000

composition

Sulfur Content, 8-13%

loss

≤10% loss on drying

color

white to off-white

useful pH range

6.0-8 (10 g/L)

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

storage temp.

room temp

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General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate increases binding of epithelial cells and lymphocytes to extracellular matrix proteins including fibronectin and laminin. In addition, dextran sulfate altered expreβion of cell surface receptors integrins.
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.

Preparation Note

Sigma dextrans are derived from Leuconostoc mesenteroides.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

52423-VAR:
52423-BULK:
52423-25G:
52423-5G:
52423-100G:

Certificates of Analysis (COA)

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J Ni et al.
Gut, 39(2), 234-241 (1996-08-01)
The effects of dextran sulphate sodium (DSS) on mouse intestinal epithelial cells and intraepithelial lymphocytes were analysed to investigate the mechanism by which DSS induces colitis and tumours in mice. Cytotoxicity of DSS towards intestinal epithelial cells and intestinal intraepithelial
Jiang-Hua Liu et al.
Disease models & mechanisms, 13(11) (2020-10-10)
Improving revascularization is one of the major measures in fracture treatment. Moderate local inflammation triggers angiogenesis, whereas systemic inflammation hampers angiogenesis. Previous studies showed that Akkermansia muciniphila, a gut probiotic, ameliorates systemic inflammation by tightening the intestinal barrier. In this
Aaron H Rose et al.
Inflammatory bowel diseases, 21(9), 2005-2015 (2015-06-16)
An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and

Articles

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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