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Safety Information

51800C

Sigma-Aldrich

Claycomb Medium

without L-glutamine, liquid, sterile-filtered, suitable for cell culture

Synonym(s):

HL-1 Medium

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.75

description

For research or for further manufacturing use.

sterility

sterile-filtered

form

liquid

storage condition

protect from light

technique(s)

cell culture | mammalian: suitable

components

L-glutamine: no

shipped in

ambient

storage temp.

2-8°C

Application

Claycomb Medium, named after Dr. William Claycomb who established the HL-1 cell line, is specifically designed for the growth of murine cardiomyocytes. HL-1 is the first cell line established that can maintain the differentiated cardiomyocyte phenotype and contractile activity in vitro. The HL-1 cell line can be used for the study of cardiac cell hypertrophy that follows myocardial infarction, the testing of novel cardiac therapeutic drugs and treatments, the production of high levels of cardiac proteins and the study of mature cardiomyocyte specific genes. Claycomb Medium, when supplemented with 100 μM norepinephrin, 10% fetal bovine serum (FBS) and 4 mM L-glutamine, will maintain the HL-1 cell line and the mature cardiomycyte behavior. While observing the HL-1 cells under light microscopy, individual and groups of cells can be observed contracting, becoming more frequent as the cardiomyocytes reach confluency.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Alcohols
Hazardous rank II

JAN Code

51800C-PH:
51800C-BULK:
51800C-500ML:
51800CPROC:
51800-500M:

Certificates of Analysis (COA)

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