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Safety Information

30423

Sigma-Aldrich

3-(Dansylamino)phenylboronic acid

BioReagent, suitable for fluorescence, ≥98.0% (HPLC)

Synonym(s):

3-(5-Di­methyl­amino­naphtha­lene-1-sulfonyl­amino)­benzene­boronic acid, 3-(Dansylamido)benzeneboronic acid

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About This Item

Empirical Formula (Hill Notation):
C18H19BN2O4S
CAS Number:
75806-94-9
Molecular Weight:
370.23
Beilstein:
8012268
EC Number:
278-319-1
MDL number:
MFCD00042703
UNSPSC Code:
12352200
PubChem Substance ID:
57648437
NACRES:
NA.32

product line

BioReagent

Assay

≥98.0% (HPLC)

fluorescence

λex 337 nm; λem 490 nm (Protein adduct)
λex 337 nm; λem 528 nm in methanol

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc3cccc(c3)B(O)O

InChI

1S/C18H19BN2O4S/c1-21(2)17-10-4-9-16-15(17)8-5-11-18(16)26(24,25)20-14-7-3-6-13(12-14)19(22)23/h3-12,20,22-23H,1-2H3

InChI key

TYXMKSYBCDTGDU-UHFFFAOYSA-N

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Application

Carbohydrate ligand in cell studies; potent boronic acid serine protease inhibitor.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

30423-100MG:
30423-BULK:
30423-100MG-BULK:
30423-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG1600
BCCB2205
BCBX0970
BCBW1585
BCBS5668V

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Inhibition of subtilisin by substituted arylboronic acids.
M Philipp et al.
FEBS letters, 133(1), 36-38 (1981-10-12)
Y Hayashi et al.
Clinica chimica acta; international journal of clinical chemistry, 149(1), 13-19 (1985-06-30)
A simple and rapid fluorometric assay of glycosylated albumin was developed using dansylated phenyl boronic acid (N-(5-dimethyl amino-1-naphthalene sulfonyl)-3-aminobenzene boronic acid). The emission spectrum of the reagent changes upon binding to cis-diols present on glycosylated albumin in serum, allowing quantitation
P Vainio
Biochimica et biophysica acta, 746(3), 217-219 (1983-08-16)
Resonance energy transfer was used to monitor the interaction of an active-site-directed fluorescent inhibitor, N-(5-dimethylaminonaphthalene-1-sulfonyl)-3-aminobenzene boronic acid, and lipoprotein lipase (EC 3.1.1.34). The binding of this probe to the active site of lipoprotein lipase had an association constant, Ka, of
Synthesis of a fluorescent boronic acid which reversibly binds to cell walls and a diboronic acid which agglutinates erythrocytes.
T J Burnett et al.
Biochemical and biophysical research communications, 96(1), 157-162 (1980-09-16)

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