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18887

Millipore

Byzen Pro™ Protein A resin

suitable for affinity chromatography

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About This Item

UNSPSC Code:
13111000
NACRES:
NA.56

form

suspension

Quality Level

100

technique(s)

affinity chromatography: suitable

mean particle size

70 μm

storage temp.

2-8°C

Application

Byzen Pro™ Protein A resin is an affinity chromatography medium in which a novel Protein A mutant is used as a ligand. Conventional protein A resins use strongly acidic buffers to elute antibodies, exposing the target antibody to the risks of aggregation and decreased activities. In contrast, this temperature- responding Byzen Pro™ Protein A resin allows antibodies to be eluted under neutral pH by a simple temperature change. This eliminates any risk of aggregation and decreased activity of the antibody, improving manufacturing efficiency for pharmaceutical antibodies.

Features and Benefits

Typical Product Profile:
Bead Structure, Cross-linked polyvinyl alcohol, Mean Particle Size 70 μm, Max. Back Pressure 0.3 MPa, Flow Rate (Recommended) 125-250 cm/h, pH Range (Recommended) pH 6-8, Ligand: Recombinant Protein A mutant, Ligand Immobilization: Multiple ligation, Dynamic Binding Capacity (20 cm column): 26 g/L (250 cm/h) 34 g/L (125 cm/h), Total Binding Capacity 40 g/L, Binding Temperature Below 10°C, Eluting Temperature 37 to 40°C, Mode of Temperature Change: Conventional heat exchange system can be used.

Legal Information

Byzen Pro is a trademark of Nomadic Bioscience Co., Ltd

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

18887-1ML:
18887-BULK:
18887-VAR:
18887-25ML-BULK:
18887-5ML:
18887-25ML:
18887-2ML:
18887-5ML-BULK:
18887-2ML-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCBZ8027
BCBV2996
BCBV3010
BCBS6163V
BCBS5775V

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Ichiro Koguma et al.
Journal of chromatography. A, 1305, 149-153 (2013-07-31)
We attempted to evaluate a novel purification method of immunoglobulins (IgGs) by using a mutant type of protein A. Although this mutant protein A binds to IgGs at 5°C, the IgGs are released at 40°C; hence, it was designated as

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