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Safety Information

71778

Sigma-Aldrich

Sodium nitroprusside dihydrate

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99%

Synonym(s):

Nitroprusside sodium, SNP, Sodium nitroferricyanide, Sodium pentacyanonitrosylferrate

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About This Item

Linear Formula:
Na2[Fe(CN)5NO] · 2H2O
CAS Number:
13755-38-9
Molecular Weight:
297.95
EC Number:
238-373-9
MDL number:
MFCD00149192
UNSPSC Code:
12352300
PubChem Substance ID:
329763522
NACRES:
NB.24
form:
crystals or chunks
solubility:
water: soluble(lit.)

grade

ACS reagent
puriss. p.a.

Quality Level

200

Agency

reag. Ph. Eur.
suitable for SM 4500 - NH3

Assay

≥99%

form

crystals or chunks

solubility

water: soluble(lit.)

anion traces

chloride (Cl-): ≤100 mg/kg
hexacyanoferrate(II) ([Fe(CN)6]4-): ≤200 mg/kg
hexacyanoferrate(III) ([Fe(CN)6]3-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤50 mg/kg
Cu: ≤5 mg/kg
K: ≤3000 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤50 mg/kg

SMILES string

O.O.[Na+].[Na+].O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N

InChI

1S/5CN.Fe.NO.2Na.2H2O/c5*1-2;;1-2;;;;/h;;;;;;;;;2*1H2/q;;;;;2*-1;2*+1;;

InChI key

OIRZWVYIQXBRFC-UHFFFAOYSA-N

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General description

Sodium nitroprusside dihydrate (Disodium pentacyanonitrosylferrate(2-)dihydrate, SNP) molecule contains a ferrous ion in the center, which is surrounded by five cyanide groups and a nitrosyl group. Sodium nitroprusside has clinical applications. It acts as a rapid-acting vasodilator. It is also widely employed as nitric oxide (NO) donor in various experimental models. Two metastable states of sodium nitroprusside dihydrate, Na2[Fe(CN)5NO].2H2O have been identified and their geometries have been studied by X-ray diffraction.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

71778-100G:4548173178714
71778-25G:4548173178721
71778-VAR-D:
71778-BULK:
71778-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCD2943
BCCB2459

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M Chiusa et al.
European journal of histochemistry : EJH, 56(2), e15-e15 (2012-06-13)
Sodium nitroprusside (SNP) is used clinically as a rapid-acting vasodilator and in experimental models as donor of nitric oxide (NO). High concentrations of NO have been reported to induce cardiotoxic effects including apoptosis by the formation of reactive oxygen species.
Aamer Sandoo et al.
Arthritis research & therapy, 13(3), R99-R99 (2011-06-23)
Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcirculation and the macrocirculation, and these manifestations might be
Diffraction studies of photoexcited crystals: Metastable nitrosyl-linkage isomers of sodium nitroprusside.
Carducci MD, et al.
Journal of the American Chemical Society, 119(11), 2669-2678 (1997)
Jae Hyung Kim et al.
Journal of applied physiology (Bethesda, Md. : 1985), 107(4), 1249-1257 (2009-08-08)
There is increasing evidence that upregulation of arginase contributes to impaired endothelial function in aging. In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores
Brittany G Durgin et al.
JCI insight, 4(19) (2019-09-06)
Nitric oxide regulates BP by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle cells (SMCs). We previously showed that sGC heme iron reduction (Fe3+ → Fe2+) is modulated by cytochrome b5 reductase
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