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Y0001183

Trolamine impurity B

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Diethanolamine, 2,2′-Iminodiethanol, Bis(2-hydroxyethyl)amine

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About This Item

Linear Formula:
HN(CH2CH2OH)2
CAS Number:
111-42-2
Molecular Weight:
105.14
Beilstein:
605315
MDL number:
MFCD00002843
UNSPSC Code:
41116107
PubChem Substance ID:
329831296
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

3.6 (vs air)

vapor pressure

<0.98 atm ( 100 °C)

API family

trolamine

autoignition temp.

689 °F

expl. lim.

10.6 %

manufacturer/tradename

EDQM

refractive index

n20/D 1.477 (lit.)

bp

217 °C/150 mmHg (lit.)

mp

28 °C (lit.)

density

1.097 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OCCNCCO

InChI

1S/C4H11NO2/c6-3-1-5-2-4-7/h5-7H,1-4H2

InChI key

ZBCBWPMODOFKDW-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Trolamine impurity B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Oral

Target Organs

Kidney,Liver,Blood

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

280.4 °F - closed cup

Flash Point(C)

138 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

Y0001183:4548173371603
Y0001183-1EA:

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Lot/Batch Number

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Choline deficiency associated with diethanolamine carcinogenicity.
Paul M Newberne
Toxicological sciences : an official journal of the Society of Toxicology, 67(1), 1-3 (2002-04-19)
Hon-Wing Leung et al.
Regulatory toxicology and pharmacology : RTP, 43(3), 260-271 (2005-09-29)
Diethanolamine (DEA) is a chemical used widely in a number of industries and is present in many consumer products. Studies by the National Toxicology Program (NTP) have indicated that lifetime dermal exposure to DEA increased the incidence and multiplicity of
M-L Metzger et al.
Clinical and experimental immunology, 179(2), 256-264 (2014-09-25)
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Hae-Rim Kim et al.
PloS one, 10(4), e0124909-e0124909 (2015-04-22)
Vascular endothelial growth factor (VEGF) has angiogenic, inflammatory, and bone-destructive roles in rheumatoid arthritis (RA). We aimed to determine the unique role of VEGF in osteoclastogenesis in RA. VEGF-induced receptor activator of nuclear factor ҡB ligand (RANKL) expression was determined
Domtila Kimani et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(11), 1992-2003 (2014-06-17)
To induce a deployable level of efficacy, a successful malaria vaccine would likely benefit from both potent cellular and humoral immunity. These requirements are met by a heterologous prime-boost immunization strategy employing a chimpanzee adenovirus vector followed by modified vaccinia
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