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SYNPLE-P072

Sigma-Aldrich

Reagent-cartridge CRBN-COOH-PEG2

Synple

Synonym(s):

Synple 2

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About This Item

MDL number:
MFCD32903606
UNSPSC Code:
12352401
NACRES:
NA.22

General description

Reagent-cartridge CRBN-COOH-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected amine to the carboxylic acid terminated linker through an amide coupling. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: carboxylic acid
Compatible substrates: amine

Cartridge contents:

  • Supported carbodiimide and Oxyma Pure (coupling reagents)
  • Supported carbonate (acid scavenger)
  • SCX2 (for purification)
  • Degrader building block linker reagent
Related Cartridges:
  • SYNPLE-P002 Reagent-cartridge CRBN-PEG2
  • SYNPLE-P003 Reagent-cartridge CRBN-PEG3
  • SYNPLE-P004 Reagent-cartridge CRBN-PEG4
  • SYNPLE-P005 Reagent-cartridge CRBN-PEG5
  • SYNPLE-P021 Reagent-cartridge VHL-PEG1
  • SYNPLE-P022 Reagent-cartridge VHL-PEG2
  • SYNPLE-P023 Reagent-cartridge VHL-PEG3
  • SYNPLE-P024 Reagent-cartridge VHL-PEG4
  • SYNPLE-P025 Reagent-cartridge VHL-PEG5
  • SYNPLE-P073 Reagent-cartridge CRBN-COOH-PEG3
  • SYNPLE-P074 Reagent-cartridge CRBN-COOH-PEG4
  • SYNPLE-P082 Reagent-cartridge VHL-COOH-PEG2
  • SYNPLE-P083 Reagent-cartridge VHL-COOH-PEG3
  • SYNPLE-P084 Reagent-cartridge VHL-COOH-PEG4
Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks.

Features and Benefits of Synple Platform
  • Time savings – pre-installed protocols have been highly optimized, which obviates the need for the user’s own reaction development and optimization
  • Easy to use – protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
  • Safety – all chemicals are contained in the system, minimizing the user’s exposure
  • Set-up reaction in less than 5 minutes
  • Small footprint
  • Plug & Play system – simple installation
  • Reaction temperatures from 25 °C – 80 °C
  • Cartridges available for many different reactions
  • Prefilled with all required reagents
  • RFID chip containing optimized reaction protocol

Other Notes

References
An integrated console for capsule-based, automatedorganic synthesis

Legal Information

Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

SYNPLE-P072-1EA:

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Certificates of Analysis (COA)

Lot/Batch Number

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