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Key Documents

Safety Information

PHR1291

Supelco

Cefazolin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Cefazolin, CFZ, Cephazolin

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About This Item

Empirical Formula (Hill Notation):
C14H14N8O4S3
CAS Number:
Molecular Weight:
454.51
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. C0682800
traceable to USP 1097603

API family

cefazolin

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

pharmaceutical

format

neat

storage temp.

2-8°C

InChI

1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1

InChI key

MLYYVTUWGNIJIB-BXKDBHETSA-N

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General description

Cefazolin is a first-generation cephalosporin β-lactam antibiotic drug that exhibits broad-spectrum antimicrobial activity against Klebsiella pneumoniae. It also acts in vitro against Gram-positive aerobic cocci while shows only a limited action on Gram-negative bacteria.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Cefazolin has been used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by thin layer chromatography-densitometry technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB0131 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

PHR1291-500MG-PW:
PHR1291-500MG:


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Certificates of Analysis (COA)

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Simultaneous identification and quantitative analysis of eight cephalosporins in pharmaceutical formulations by TLC-densitometry
Monika D, et al.
JPC-Journal of Planar Chromatography-Modern TLC, 24(1), 23-29 (2011)
Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode
El-Desoky HS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 39(5), 1051-1056 (2005)
Streamlining methodology for the multiresidue analysis of β -lactam antibiotics in bovine kidney using liquid chromatography-tandem mass spectrometry
Mastovska K and Lightfield AR
Journal of Chromatography A, 1202(2), 118-123 (2008)

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