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PHR1146

Supelco

Ibuprofen Related Compound C

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4′-Isobutylacetophenone, 1-(4-Isobutylphenyl)ethanone, 1-Acetyl-4-isobutylbenzene

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About This Item

Empirical Formula (Hill Notation):
C12H16O
CAS Number:
Molecular Weight:
176.25
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

100
300

Agency

traceable to BP 557
traceable to USP 1335541

API family

ibuprofen

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C12H16O/c1-9(2)8-11-4-6-12(7-5-11)10(3)13/h4-7,9H,8H2,1-3H3

InChI key

KEAGRYYGYWZVPC-UHFFFAOYSA-N

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General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

It is an impurity of the nonsteroidal anti-inflammatory drug (NSAID)― ibuprofen and presents itself as a degradation product of the parent drug. It is used for the treatment of mild and moderate pain such as during rheumatoid arthritis, osteoarthritis, and dysmenorrhea.

Application

This pharmaceutical secondary standard can also be used as follows:

  • Simultaneous determination of ibuprofen and its 17 related impurities by an ICH validated reversed-phase high-performance liquid chromatography (RP-HPLC) method in tablets
  • Analysis of combined dosage tablet of ibuprofen and famotidine for their quantitative estimation in the presence of their impurities using thin layer chromatography (TLC) and HPLC

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB2151 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1B

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

286.7 °F - closed cup

Flash Point(C)

141.5 °C - closed cup


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

PHR1146-500MG-PW:
PHR1146-500MG:
PHR1146-VAR:
PHR1146-500MG-BULK:


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Development and validation of an HPLC method for simultaneous determination of ibuprofen and 17 related compounds
Han Z, et al.
Chromatographia, 80, 1353-1360 (2017)

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