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Key Documents

Safety Information

MTOX1302

Sigma-Aldrich

Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells

canine kidney (cocker spaniel)

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About This Item

UNSPSC Code:
41106514
NACRES:
NA.81

Product Name

Canine MDR1 Knockout, Human BCRP/OATP2B1 double Knockin MDCKII Cells,

biological source

canine kidney (cocker spaniel)

form

liquid

shipped in

dry ice

storage temp.

−196°C

Gene Information

human ... ABCG2(9429)

General description

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP and Human OATP2B1 has been transfected into the MDCKII cell line. Validation studies have shown BCRP dependent efflux of estrone-3 sulfate (requires OATP2B1) and teriflunomide (does not require OATP2B1).

Features and Benefits

MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.

Quality

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.

Legal Information

ADME/Tox Cell Lines License and HepaRG Limited Use License

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

MTOX1302-1VL:
MTOX1302-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLBZ2955

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