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Safety Information

E1800000

Ethacrynic acid

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid

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About This Item

Empirical Formula (Hill Notation):
C13H12Cl2O4
CAS Number:
Molecular Weight:
303.14
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

ethacrynic acid

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O

InChI

1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)

InChI key

AVOLMBLBETYQHX-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethacrynic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

E1800000-1EA:
E1800000:


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[Action and mode of action of a new original diuretic: ethacrynic acid].
M Salvador et al.
Journal de medecine de Bordeaux et du Sud-Ouest, 143(8), 1105-1118 (1966-08-01)
Toxicity of ethacrynic acid and furosemide.
L B Cooperman et al.
American heart journal, 85(6), 831-834 (1973-06-01)
J H Ploemen et al.
Xenobiotica; the fate of foreign compounds in biological systems, 23(8), 913-923 (1993-08-01)
1. The diuretic drug ethacrynic acid (EA) is a potent reversible inhibitor of rat and human glutathione S-transferases (GST), with I50-values (microM) of 4.6-6.0, 0.3-1.9 and 3.3-4.8 for alpha, mu and pi-class, respectively. 2. The reversible inhibition by the glutathione
Ototoxicity of ethacrynic acid (a persistent clinical problem).
L P Rybak
The Journal of laryngology and otology, 102(6), 518-520 (1988-06-01)
[Action and mode of action of a new original diuretic: ethacrynic acid].
M Salvador et al.
Actualites cardiologiques et angeiologiques internationales, 15(2), 101-107 (1966-01-01)

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