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Safety Information

920193

Sigma-Aldrich

Cyrene™ 2-Methyltetrahydrofuran Blend

greener alternative

BioRenewable, DMF and NMP Substitute

Synonym(s):

2-MeTHF Solution, 2-Methyltetrahydrofuran solution, Cyrene solution

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About This Item

Empirical Formula (Hill Notation):
C6H8O3
Molecular Weight:
128.13
UNSPSC Code:
12352212
NACRES:
NA.07

form

liquid

contains

30-80 ppm BHT as stabilizer

greener alternative product characteristics

Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

renewable carbon content

100%

density

1.153 g/mL

greener alternative category

, Aligned

General description

Cyrene™ 2-Methyltetrahydrofuran Blend with BHT as an inhibitor is specially formulated for use in automated processes and applications where lower viscosity is required, making it easier to handle while maintaining high yields.

This Cyrene™ blend is an alternative for NMP and DMF in many cross-coupling reactions. Neither Cyrene™ nor 2-Methyltetrahydrofuran have any genotoxic or mutagenic concerns associated with their use, making them much safer alternatives to traditional aprotic solvents.

This new blend is part of our Biorenewable product line, meaning that it is made from renewable resources and does not compete with food resources for its production, making it more environmentally sustainable for the future. The material has also been independently certified as 100% renewable carbon.
We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product is BioRenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks". Click here for more information.

Application

This cosolvent solution has been shown to have similar reaction yields to NMP and DMF for many cross-coupling reactions, such as:

Features and Benefits

  • Independently certified as 100% renewable carbon.
  • Closer physical properties of NMP and DMF while maintaining high reaction yields.
  • Sustainably produced and environmentally less hazardous than more traditional petroleum aprotic solvents
  • Both Cyrene and 2-MeTHF are also much safer for handling without the genotoxic concerns of other solvents.
  • It has a lower viscosity than neat Cyrene making it more optimized for automated processes.

Other Notes

To see other BioRenewable or Greener Solvents

Legal Information

CYRENE is a trademark of Circa Group Pvt Ltd

Pictograms

FlameCorrosion
GHS02,GHS05

Signal Word

Danger

Hazard Statements

H225,H315,H318

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 2 - Skin Irrit. 2

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

920193-VAR:
920193-100ML:
920193-BULK:
920193-1L:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBN6307

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