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917656

Sigma-Aldrich

3-(Piperidin-4-yl)benzoic acid hydrochloride

≥95%

Synonym(s):

Semi-flexible linker for PROTAC® development

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About This Item

Empirical Formula (Hill Notation):
C12H16ClNO2
CAS Number:
726185-55-3
Molecular Weight:
241.71
MDL number:
MFCD08460727
UNSPSC Code:
12352116

Quality Level

100

Assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(C1=CC(C2CCNCC2)=CC=C1)O.Cl

Application

3-(Piperidin-4-yl)benzoic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

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916854

2-(Piperidin-4-yl)benzoic acid hydrochloride, 95%

917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, ≥95%

917095

4-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917893

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

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tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

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2-(4-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916625

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917915

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(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917664

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

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(3-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

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tert-Butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916587

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917850

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

917656-VAR:
917656-BULK:
917656-100MG:

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