Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

680303

Sigma-Aldrich

Tetrahydrofuran solution

contains 20 % (v/v) 1,2-Propanediol

Synonym(s):

Butylene oxide, Oxolane, THF, Tetramethylene oxide

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:

form

liquid

Quality Level

contains

20 % (v/v) 1,2-Propanediol

impurities

≤0.20% water
0.02 meq/g Titr. acid
0.02 meq/g Titr. base

color

APHA: 1

density

0.914 g/mL at 25 °C

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

General description

Tetrahydrofuran (THF) solution is THF in 20% (v/v) 1,2-propanediol. THF a saturated cyclic ester, is a water-miscible organic solvent. THF has been a widely used industrial solvent for varnishes and PVC (polyvinyl chloride), polymerization, electrochemistry, and pharmaceutical.
The product is a tetrahydrofuran (THF) solution containing 20%(v/v) 1,2-propanediol. THF, a saturated cyclic ester, is a water miscible organic solvent. The combustion studies of THF have been reported.

Application


  • Self-Assembly of Polyoxometalate-Based Nanoparticle Surfactants in Solutions: Highlights the use of Tetrahydrofuran as a critical solvent in the synthesis and self-assembly of polyoxometalate-based nanoparticles, exploring applications that could impact multiple fields including polymer research, drug delivery systems, and nanostructured materials (Xia et al., 2024).

  • Highly sensitive fluorescence turn-OFF and reversible chemical sensor for Hg(2+) ion based on pyrene appended 2-thiohydantoin: Tetrahydrofuran is used as a key solvent in the development of a novel fluorescence-based chemical sensor for mercury detection, demonstrating its application in environmental monitoring and safety in laboratory settings (Gawas et al., 2024).

  • Effect of Plasma pretreatment and Graphene oxide ratios on the transport properties of PVA/PVP membranes for fuel cells: This research employs Tetrahydrofuran as a processing solvent in the creation of polyvinyl alcohol/polyvinylpyrrolidone membranes enhanced with graphene oxide, focusing on improvements in ion transport for fuel cell applications (Abdel-Hamed et al., 2024).

  • Optimized Incorporation of Furan into Diketopyrrolopyrrole-Based Conjugated Polymers for Organic Field-Effect Transistors: Utilizes Tetrahydrofuran as a solvent to aid in the synthesis of novel conjugated polymers, potentially leading to advancements in organic electronics and polymer research (Neu et al., 2024).

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

-6.2 °F - (THF)

Flash Point(C)

-21.2 °C - (THF)

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

680303-4X4L:4548173272511
680303-BULK:
680303-4L:4548173272504
680303-VAR:


Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen) CoIII complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols.
Schaus SE, et al.
Journal of the American Chemical Society, 124(7), 1307-1315 (2002)
An experimental and modeling study of the combustion of tetrahydrofuran.
Tran LS, et al.
Combustion and Flame, 162(5), 1899-1918 (2015)
Ilaria Massarelli et al.
European journal of medicinal chemistry, 44(9), 3658-3664 (2009-03-11)
A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above unwanted property for New Chemical Entities. The dataset was rationally split into
Anita Toulmin et al.
Journal of medicinal chemistry, 51(13), 3720-3730 (2008-06-19)
Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the partitioning systems are not well represented in the literature
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service