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Safety Information

52517

Supelco

1,1,1,3,3,3-Hexafluoro-2-propanol

for GC derivatization, LiChropur™, ≥99.8%

Synonym(s):

HFP, Hexafluoroisopropanol

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About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
920-66-1
Molecular Weight:
168.04
Beilstein:
1841007
EC Number:
213-059-4
MDL number:
MFCD00011651
UNSPSC Code:
12352104
PubChem Substance ID:
329757847
NACRES:
NA.05

grade

for GC derivatization

Quality Level

100

Assay

≥99.8% (GC)
≥99.8%

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

SMILES string

OC(C(F)(F)F)C(F)(F)F

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

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General description

Hexafluoroisopropanol (HFP) is generally used to denature the native state of proteins, and it also stabilizes the a-helical conformation in unfolded peptides and proteins like ß-lactoglobulin and melittin.

Application

Suitable for the derivatization of glutamic acid, homovanillic, iso-homovanillic and dihydroxyphenyl acetic acids and Υ-aminobutyric acid.

Other Notes

Reagent for hexafluoroisopropyl ester, N-pentafluoropropionyl, and trifluoroacetyl..
Size-exclusion chromatography in 1,1,1,3,3,3-hexafluoro-2-propanol

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H361,H373

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

No data available

Flash Point(C)

No data available

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

52517-10ML:
52517-VAR:
52517-50ML:
52517-1ML-KC:
52517-10X1ML:
52517-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0248
BCCG7310
BCCG5092
BCCG0003
BCCF7882

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Thomas H Mourey et al.
Journal of chromatography. A, 964(1-2), 169-178 (2002-08-30)
1,1,1,3,3,3-Hexafluoroisopropanol is re-examined as an eluent for size-exclusion chromatography (SEC) of polyesters, nylons, and other polar polymers. It is shown that anomalous SEC behavior reported in previous literature can be eliminated by adding 0.01 M tetraethylammonium nitrate to the eluent.
Cooperative a-helix formation of ?-lactoglobulin and melittin induced by hexafluoroisopropanol
Hirota, Nami, Yuji Goto, and Kazuko Mizuno.
Protein Science, 6 (2), 416-421 (1997)
Sriya Das et al.
ACS applied materials & interfaces, 3(6), 1844-1851 (2011-05-05)
We demonstrate a novel in situ polymerization technique to develop localized polymer coatings on the surface of dispersed pristine graphene sheets. Graphene sheets show great promise as strong, conductive fillers in polymer nanocomposites; however, difficulties in dispersion quality and interfacial
Dave W Chen et al.
International journal of pharmaceutics, 430(1-2), 335-341 (2012-04-24)
This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/vancomycin/gentamicin/lidocaine were separately dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). They were then electrospun into
Benjamin H Rotstein et al.
Chemical communications (Cambridge, England), 48(31), 3775-3777 (2012-03-21)
A novel class of reagents, thioester isocyanides, have been prepared and applied in the synthesis of peptide macrocycles. The isocyanide part of the molecule is deployed in a multicomponent macrocyclization step. This step is followed by chemoselective peptide ligation at
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