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49761

Supelco

Spermidine

analytical standard

Synonym(s):

1,8-Diamino-4-azaoctane, N-(3-Aminopropyl)-1,4-diaminobutane

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About This Item

Linear Formula:
NH2(CH2)3NH(CH2)4NH2
CAS Number:
124-20-9
Molecular Weight:
145.25
Beilstein:
1698591
EC Number:
204-689-0
MDL number:
MFCD00008229
UNSPSC Code:
85151701
PubChem Substance ID:
329757521
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.5% (NT)
≥99.0% (GC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.479 (lit.)

density

0.925 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care

format

neat

storage temp.

2-8°C

SMILES string

NCCCCNCCCN

InChI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

InChI key

ATHGHQPFGPMSJY-UHFFFAOYSA-N

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General description

Spermidine is a naturally occurring polyamine compound commonly found in food. It is essential for cell growth and survival.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Spermidine may be used as one of the reference standard for the determination of spermidine in biological samples by high performance liquid chromatography-electrospray ionization–ion trap tandem mass spectrometry (HPLC–ESI–ITMS/MS).

Biochem/physiol Actions

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

233.6 °F - closed cup

Flash Point(C)

112 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

49761-BULK:
49761-100MG:
49761-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3819
BCCF5855
BCCD8632
BCCD2772
BCCB7355

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Determination of putrescine, cadaverine, spermidine and spermine in different chemical matrices by high performance liquid chromatography?electrospray ionization?ion trap tandem mass spectrometry (HPLC?ESI?ITMS/MS).
Ibarra A A G, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1002, 176-184 (2015)
Micro-scale strategy to detect spermine and spermidine by MALDI?TOF MS in foods and identification of apoptosis-related proteins by nano-flow UPLC?MS/MS after treatment with spermine and spermidine
Su H H, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 978, 131-137 (2015)
Varun K Gupta et al.
Nature neuroscience, 16(10), 1453-1460 (2013-09-03)
Age-dependent memory impairment is known to occur in several organisms, including Drosophila, mouse and human. However, the fundamental cellular mechanisms that underlie these impairments are still poorly understood, effectively hampering the development of pharmacological strategies to treat the condition. Polyamines
Eugenia Morselli et al.
Aging, 1(12), 961-970 (2010-02-17)
Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced by our groups demonstrates that
Andrew Breakspear et al.
The Plant cell, 26(12), 4680-4701 (2014-12-21)
Nitrogen-fixing rhizobia colonize legume roots via plant-made intracellular infection threads. Genetics has identified some genes involved but has not provided sufficient detail to understand requirements for infection thread development. Therefore, we transcriptionally profiled Medicago truncatula root hairs prior to and
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Protocols

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

HPLC Analysis of Biogenic Amines on Ascentis® RP-Amide

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