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402923

Sigma-Aldrich

Chloroacetic acid

ACS reagent, ≥99.0%

Synonym(s):

Monochloroacetic acid

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5000 UNITS
$515.46
10000 UNITS
$879.67
25000 UNITS
$2,044.90

About This Item

Linear Formula:
ClCH2COOH
CAS Number:
79-11-8
Molecular Weight:
94.50
Beilstein:
605438
EC Number:
201-178-4
MDL number:
MFCD00002683
UNSPSC Code:
12352100
PubChem Substance ID:
24865140
NACRES:
NA.21

$515.46

Estimated to ship onMay 17, 2025

Request a Bulk Order

grade

ACS reagent

Quality Level

200

vapor density

3.26 (vs air)

vapor pressure

0.75 mmHg ( 20 °C)

Assay

≥99.0%

form

solid

impurities

≤0.01% Carbonyl compounds (as acetone)
≤0.01% Carbonyl compunds (other than acetone)
≤0.01% insolubles

ign. residue

<0.02%

bp

189 °C (lit.)

mp

60-63 °C (lit.)

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assay

≥98% (HPLC)

assay

>97.5% (HPLC)

assay

≥98%

assay

>99% (TLC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

-

storage temp.

room temp

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL

solubility

DMSO:methanol (1:1): 50 mg/mL, clear, orange

solubility

-

solubility

-

color

red

color

orange to red

color

-

color

-

General description

Chloroacetic acid (CAA, monochloroacetic acid, MCAA) is a halogenated aliphatic carboxylic acid. Its mutagenic effects have been studied in Rattus norvegicus.[1] The rate of degradation of MCA by photocatalysis using TiO2 at pH3 is reported to be enhanced under the influence of ozone.[2] CAA is an irritant that hydrolyzes proteins resulting in degradation of the cells. This property has been applied in treating plantar warts.[3]

Application

Chloroacetic acid may be used to synthesize the following:
  • Thiocarbamoylthioacetic acid derivatives.[4]
  • 4-Thiazolone derivatives.[5]
  • Triazinothiazolone derivatives.[6]
  • Water soluble carboxymethyl chitosan.[7]

Disclaimer

“The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.”

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

258.8 °F - closed cup

Flash Point(C)

126 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

402923-BULK:
402923-100G:4548173145716
402923-4X2KG:4548173264622
402923-VAR:
402923-500G:4548173145730
402923-2KG:4548173145723
402923-6X500G:4548173264639

  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCQ9526
    MKCQ9527
    MKCQ8245
    MKCP6880
    MKCP4193

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    Desulfurization of N-Substituted 2-Thioxothiazolidin-4-ones in Aqueous Solutions of Chloroacetic Acid.
    Orlinskii MM.
    Russ. J. Org. Chem., 34(12), 1805-1806 (1998)
    A Novel Three-Component Synthesis of Triazinothiazolones.
    Holla BS, et al.
    Synthetic Communications, 35(3), 333-340 (2005)
    Novel thiazolone derivatives of N-aryl-β-alanines.
    Stasevych M, et al.
    Chemistry of Heterocyclic Compounds, 47(8), 1050-1052 (2011)
    Mohammad Faisal Siddiqui et al.
    Ecotoxicology and environmental safety, 65(2), 159-164 (2006-05-02)
    Chloroacetic acid (CAA) and chlorobenzene (CB) have been evaluated for in vivo mutagenic potential in Rattus norvegicus, employing the following criteria : (i) chromosomal aberrations (CAs) such as breaks, gaps, exchanges, rings, and multiple aberrations and (ii) micronuclei (MN) induction.
    TiO2 photocatalytic oxidation of monochloroacetic acid and pyridine: influence of ozone.
    Kopf P, et al.
    Journal of Photochemistry and Photobiology A: Chemistry, 136(3), 163-168 (2000)
    View All Related Papers

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