34888-M

Acetonitrile

≥99.9%, for HPLC, for UV, suitable for HPLC

• Synonym(s): ACN, Cyanomethane, Ethyl nitrile, Methyl cyanide
• Linear Formula: CH₃CN
• CAS Number: 75-05-8
• Molecular Weight: 41.05
• Beilstein: 741857
• EC Number: 200-835-2
• MDL number: MFCD00001878
• UNSPSC Code: 41116004
• NACRES: NA.03
• technique(s): HPLC: suitable
• bp: 81-82 °C (lit.)
• vapor pressure: 72.8 mmHg ( 20 °C)

Properties

• Product Name: Acetonitrile, ≥99.9%
• vapor density: 1.41 (vs air)
• vapor pressure: 72.8 mmHg ( 20 °C)
• Assay: ≥99.9%
• form: liquid
• autoignition temp.: 973 °F
• expl. lim.: 16 %
• technique(s): HPLC: suitable
• impurities: ≤0.0002% free alkali (NH₃); ≤0.002% free acid (as CH₃COOH); ≤0.02% water; ≤0.5 ppb fluorescence (quinine) at 365 nm; ≤1 ppb fluorescence (quinine) at 254 nm
• evapn. residue: ≤0.0005%
• transmittance: 195 nm, ≥65%; 200 nm, ≥88%; 210 nm, ≥93%; 235 nm, ≥99%
• refractive index: n20/D 1.344 (lit.)
• bp: 81-82 °C (lit.)
• mp: −45 °C (lit.)
• density: 0.786 g/mL at 25 °C (lit.)
• format: neat
• SMILES string: CC#N
• InChI: 1S/C2H3N/c1-2-3/h1H3
• InChI key: WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Acetonitrile is a widely used organic solvent in reversed-phase liquid chromatography due to its high miscibility with water, suitable UV absorbance properties, and low viscosity characteristics.

Application

Acetonitrile can be used as a component in:

• Mobile phase mixture for the HPLC analysis, to determine the purity of ester content (%FAME).
• Mobile phase for the ultra-performance liquid chromatography (UPLC) analysis of perfluoroalkyl carboxylic and sulfonic compounds.
• Mobile phase for high-performance liquid chromatography (HPLC), enabling the effective separation of TMP (trimethoprim) and SMX (sulfamethoxazole).
• For sample preparation, including extraction, dilution, and dissolutionof compounds prior to analysis.

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - closed cup
• Flash Point(C): 2.0 °C - closed cup