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Safety Information

31593

Supelco

Arecoline hydrobromide

VETRANAL®, analytical standard

Synonym(s):

1-Methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid methyl ester hydrobromide, Arecaidine methyl ester hydrobromide, Methyl 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylate hydrobromide, Methyl 1-methyl-1,2,5,6-tetrahydronicotinate hydrobromide, Taeniolin

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About This Item

Empirical Formula (Hill Notation):
C8H13NO2 · HBr
CAS Number:
300-08-3
Molecular Weight:
236.11
Beilstein:
3914826
EC Number:
206-087-3
MDL number:
MFCD00039041
UNSPSC Code:
41116107
PubChem Substance ID:
329753838
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

172-176 °C (lit.)

application(s)

clinical
food and beverages

format

neat

SMILES string

Br[H].COC(=O)C1=CCCN(C)C1

InChI

1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H

InChI key

AXOJRQLKMVSHHZ-UHFFFAOYSA-N

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General description

Arecoline hydrobromide is an arecoline salt of hydrobromic acid generally used in removing parasites from dog′s intestine. It has a strong parasympathomimetic action.

Application

Arecoline hydrobromide may have been used as working standard in the determination of arecoline concentration from dog plasma using LC–MS/MS.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

31593-250MG:
31593-VAR:
31593-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG1823
BCBT6367
BCBS1213V
SZBG005XV
SZBE092XV

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THE RELATION BETWEEN METHOD OF ADMINISTRATION, ROUTE OF ABSORPTION, INHIBITORY ACTIONS AND ACUTE TOXICITY OF ARECOLINE HYDROBROMIDE IN DOGS.
FORBES LS.
Annals of Tropical Medicine and Parasitology, 58, 119-131 (1964)
Sarah L Withey et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 397-409 (2018-05-23)
Evidence suggests that the α4β2, but not the α7, subtype of the nicotinic acetylcholine receptor (nAChR) plays a key role in mediating the behavioral effects of nicotine and related drugs. However, the importance of other nAChR subtypes remains unclear. The
A Dakkak et al.
Acta tropica, 165, 26-32 (2016-07-21)
This study was undertaken in the Province of Sidi Kacem in northwest Morocco between April 2010 and March 2011. The main objective of the study was to determine the prevalence of Echinococcus granulosus (Eg) infection in owned dogs. This province
Osamu Uehara et al.
Oncology letters, 14(1), 1186-1192 (2017-07-12)
Betel quid chewing is implicated in the high prevalence of oral cancer in Southeast Asian countries. One of the major components of betel quid is arecoline. In the present study, in order to characterize the association between chronic arecoline stimulation
Vipin Jain et al.
Journal of agricultural and food chemistry, 65(9), 1977-1983 (2017-02-14)
Chewing of areca nut in different forms such as betel quid or commercially produced pan masala and gutkha is common practice in the Indian subcontinent and many parts of Asia and is associated with a variety of negative health outcomes
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