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Safety Information

15522

Sigma-Aldrich

D-(+)-Galactose

meets analytical specification of Ph. Eur., BP

Synonym(s):

Galactose

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About This Item

Empirical Formula (Hill Notation):
C6H12O6
CAS Number:
59-23-4
Molecular Weight:
180.16
Beilstein:
1724619
EC Number:
200-416-4
MDL number:
MFCD00151230
UNSPSC Code:
12352201
PubChem Substance ID:
57647466
NACRES:
NA.21

form

powder

Quality Level

200

quality

meets analytical specification of Ph. Eur., BP

technique(s)

IR spectroscopy: suitable

impurities

acid. or alk. react. impurities, in accordance
 microbiological impurity, in accordance
 residual solvents, in accordance
≤1.0% water (Karl Fischer)

color

white

useful pH range

5.0-7.0 (25 °C, 180 g/L)

mp

168-170 °C (lit.)

solubility

H2O: soluble 180 g/L at 20 °C

suitability

in accordance for appearance of solution
in accordance for identity (IR)

application(s)

pharmaceutical (small molecule)

SMILES string

OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O

InChI

1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6-/m0/s1

InChI key

GZCGUPFRVQAUEE-KCDKBNATSA-N

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Application

D-(+)-Galactose was used for examining the specificity of staining with SBA-FITC during labeling of cells for fluorescence-activated cell sorting (FACS). It was used for selecting the transformed strains of S. cerevisiae.

Biochem/physiol Actions

Galactose is a monosaccharide sugar and is the natural antigen present on the blood cells. It induces memory loss, neurodegeneration as well as oxidative damage in mice due to systemic exposure.
Galactose is a simple monosaccharide that serves as an energy source and as an essential component of glycolipids and glycoproteins. Galactose contributes to energy metabolism via its conversion to glucose by the enzymes that constitute the Leloir pathway. Defects in the genes encoding these proteins lead to the metabolic disorder galactosemia.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

15522-1.5KG-R:
15522-VAR-R:
15522-1KG-R:
15522-BULK-R:
15522-6X100G-R:
15522-250G-R:
15522-100G-R:
15522-6X1KG-R:
15522-6X250G-R:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG8311
BCCF3056
BCCD1181
BCBS5475
1355173V

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Elizabeth M Prescott et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(13), 8796-8801 (2002-06-22)
Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination
Xu Cui et al.
Journal of neuroscience research, 84(3), 647-654 (2006-05-20)
Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model. The underlying mechanism is yet unclear. To investigate the mechanisms of neurodegeneration in this model, we studied
P J Simmons et al.
Blood, 78(11), 2848-2853 (1991-12-01)
Normal bone marrow cells were isolated by fluorescence-activated cell sorting (FACS) on the basis of CD34 antigen expression and then assayed in vitro for colonies of fibroblastic cells (fibroblast colony-forming units [CFU-F]). Greater than 95% of detectable CFU-F were recovered
L Mortimer et al.
Mucosal immunology, 7(4), 829-841 (2013-11-21)
Entamoeba histolytica (Eh) is an extracellular protozoan parasite of the human colon, which occasionally breaches the intestinal barrier. Eradicating ameba that invades is essential for host survival. A defining but uncharacterized feature of amebic invasion is direct contact between ameba
Cheryl M Koh et al.
The Journal of clinical investigation, 125(5), 2109-2122 (2015-04-22)
Constitutively active MYC and reactivated telomerase often coexist in cancers. While reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with cofactors, confers several growth advantages to cancer cells. It is known that the reactivation
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