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Safety Information

SCT264

Sigma-Aldrich

BioTracker™ Mitophagy Live Cell Probe

Human

Synonym(s):

mitochondrial degradation probe, mitophagy detection, mitophagy probe

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About This Item

UNSPSC Code:
41106514
NACRES:
NB.12

Product Name

BioTracker™ Mitophagy Live Cell Probe,

biological source

human

Quality Level

100

form

lyophilized solid

packaging

vial of 15 μg

manufacturer/tradename

Millipore

technique(s)

cell culture | stem cell: suitable

shipped in

2-8°C

storage temp.

2-8°C

General description

The Mitophagy probe accumulates in intact mitochondria, where it is immobilized by chemical bonds and exhibits a weak fluorescence under normal conditions. When mitophagy is induced, the damaged mitochondria fuse with the lysosome, increasing fluorescence


SPECTRAL PROPERTIES
λex: 530 nm
λem: 700 nm

A 100 uM stock solution of the mitophagy probe is created by dissolving 50 uL DMSO to one tube (5 ug) of mitophagy dye.
A typical working solution concentration is 1 nM.

Features and Benefits

SCT264 live cell mitophagy detection probe accumulates and is immobilized on intact mitochondria, which fuse to the lysosome after mitophagy is induced, causing the probe to fluoresce brightly. Mitophagy has been associated with the accumulation of dysfunctional mitochondria in diseases such Alzheimer′s and Parkinson′s.

Target description

Mitochondria play an essential role in cells for the production of energy. Mitophagy, or the removal of damaged mitochondria via autophagy, has been connected to Alzheimer s and Parkinson s disease induced by the accumulation of depolarized mitochondria. Mitophagy serves as a dedicated elimination system that removes mitochondria whose dysfunction may be caused by oxidative stress and DNA damage. Mitochondria destined for autophagy are sequestered into the autophagosome, fused to the lysosome, and digested.

Physical form

purple solid

Storage and Stability

Store at 2 - 8 °C, protected from light.

Other Notes

This far red live cell probe for mitophagy detection fluoresces brightly when damaged mitochondria enter the acidic environment of the lysosome.

Legal Information

BioTracker is a trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SCT264-5UG:
SCT264:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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