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Safety Information

SCT092

Sigma-Aldrich

BioTracker PyrPeg Amyloid-b Live Cell Dye

Synonym(s):

BioTracker PyrPeg Amyloid-b Live Cell Dye

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About This Item

UNSPSC Code:
12352207
NACRES:
NA.47

form

lyophilized

mol wt

calculated mol wt 459.49

packaging

pkg of 1 mg

manufacturer/tradename

Millipore

storage condition

protect from light

growth mode

N/A

shipped in

ambient

storage temp.

−20°C

General description

Alzheimer′s disease (AD) is a progressive neurological disorder characterized by the presence of amyloid-beta (Aβ) plagues and neurofibrillary tangles. The accumulation of Aβ plaques is an early event in the pathogenesis of AD. In AD research, there has been a growing need for in vivo Aβ imaging by two-photon microscopy, which enables deep-brain-fluorescence imaging. BioTracker PyrPeg Amyloid-b Live Cell Dye is a two-photon fluorescent probe that specifically detects insoluble Aβ, rather than tau and alpha-synuclein aggregates (1). This probe may serve as a useful blood-brain-barrier penetrating tool for optical and functional monitoring of insoluble forms of Aβ aggregates in the AD model brain (1).Reference:1. Choi, Ji-Woo, et al. "PyrPeg, a Blood–Brain-Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, Not Tau Aggregates." ACS Chemical Neuroscience 11.12 (2020): 1801-1810.

Application

Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.

Features and Benefits

Two-photon fluorescent probe for imaging insoluble forms of Amyloid-beta aggregates in Alzheimer′s disease studies.

Physical form

Lyophilized. Orange solid.

Storage and Stability

Store at -20°C, desiccate and protect from light.
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SCT092:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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