SCC188
GN11 Mouse GnRH Neuronal Cell Line
The GN11 mouse neuronal cell line is an immortalized cell line established as a model of GnRH-secreting neurons.
Synonym(s):
GN11 cell line
About This Item
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packaging
vial of ≥1X10⁶ cells
technique(s)
cell culture | mammalian: suitable
input
sample type neural cells (lineage)
General description
Gonadotropin-releasing hormone (GnRH) is important for control of reproduction in all mammals, acting to stimulate the synthesis and secretion of follicle-stimulating hormone and luteinizing hormone from the pituitary gland (1).GnRH is secreted by specialized neurons that migrate from the olfactory bulb to the brain during embryonic development. GnRH neurons are highly sensitive to glucose and insulin, suggestive of their physiological role in sensing the metabolic status in preparation for reproduction (2). Defects in GnRH neuronal function result in subfertility and developmental abnormalities. The scattered distribution and scarcity of GnRH neurons in the brain complicate the in vivo study of these cells and necessitate the utilization of robust in vitro cell models.
The GN11 mouse neuronal cell line is an immortalized cell line established as a model of GnRH-secreting neurons (3). In addition to GnRH expression, GN11 cells display neuron-specific markers including microtubule-associated protein 2 (MAP2) and Tau (4). GN11 cells express insulin receptor (5) and are responsive to steroid hormones (6). The GN11 GnRH-secreting neuronal cell line has proven a valuable system for exploring the cellular mechanisms of neuroendocrine reproductive physiology.
Application
Packaging
Quality
- Each vial contains ≥ 1X10⁶ viable cells.
- Cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
- Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
- Cells are negative for mycoplasma contamination.
Storage and Stability
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
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ISHL Indicated Name
Substances Subject to be Indicated Names
ISHL Notified Names
Substances Subject to be Notified Names
JAN Code
SCC188:
Certificates of Analysis (COA)
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