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Safety Information

MAB5200

Sigma-Aldrich

Anti-Synaptotagmin I Antibody

Chemicon®, from mouse

Synonym(s):

p65, Syt1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

monoclonal

species reactivity

frog, bovine, chicken, rabbit, rat, shark, mouse

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_005639.1

UniProt accession no.

P21579

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SYT1(6857)

Specificity

Synaptotagmin 1, also known as p65. By Western blot MAB5200 reacts with a single protein with a molecular weight of approximately 65 kDa. MAB5200 has not been epitope mapped.

Immunogen

Rat brain synaptotagmin.

Application

Research Category
Neuroscience
Research Sub Category
Synapse & Synaptic Biology
This Anti-Synaptotagmin I Antibody is validated for use in IP, WB, IC for the detection of Synaptotagmin I.
Western blot: 5 μg/mL (colormetric) Immunocytochemistry

Immunoprecipitation

Optimal working dilutions and protocols must be determined by the end user.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in PBS with 50% glycerol and 0.09% sodium azide.

Storage and Stability

Maintain at -20°C in undiluted aliquots up to 12 months.Avoid repeated freeze/thaw cycles.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB5200:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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M Shao et al.
Neuroscience, 161(4), 988-1007 (2009-04-21)
Vestibular compensation refers to the behavioral recovery after a unilateral peripheral vestibular lesion. In chickens, posture and balance deficits are present immediately following unilateral vestibular ganglionectomy (UVG). After three days, most operated chickens begin to recover, but severe deficits persist
B Marquèze et al.
Biochimie, 82(5), 409-420 (2000-06-24)
The aim of this review is to give a broad picture of what is actually known about the synaptotagmin family. Synaptotagmin I is an abundant synaptic vesicle and secretory granule protein in neurons and endocrine cells which plays a key
AMPA receptor subunit expression in chick vestibular nucleus neurons.
Anastas Popratiloff, Ya-Xian Wang, Jared Narvid, Ronald S Petralia, Christian Giaume et al.
Journal of Neuroscience Research null
Identification of a synaptic vesicle-specific membrane protein with a wide distribution in neuronal and neurosecretory tissue
Matthew, W D, et al
The Journal of cell biology, 91, 257-269 (1981)
M Shao et al.
Neuroscience, 223, 333-354 (2012-08-09)
Unilateral damage to the peripheral vestibular receptors precipitates a debilitating syndrome of oculomotor and balance deficits at rest, which extensively normalize during the first week after the lesion due to vestibular compensation. In vivo studies suggest that GABA(B) receptor activation
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