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Safety Information

MAB447

Sigma-Aldrich

Anti-ER-alpha Antibody, clone AER314

ascites fluid, clone AER314, Chemicon®

Synonym(s):

ER, ER1, Estradiol Receptor, ER-alpha

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

antibody form

ascites fluid

antibody product type

primary antibodies

clone

AER314, monoclonal

species reactivity

mouse, rat, rabbit, bovine, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000125.2

UniProt accession no.

P03372

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ESR1(2099)

Specificity

Estrogen receptor 67kD hormone binding subunit. Epitope localized between aa 120-170.

AFFINITY:

0.8 nM

Immunogen

Bovine estrogen receptor.
Epitope: a.a. 120-170 of hER-1 alpha

Application

Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Use Anti-ER-alpha Antibody, clone AER314 (Mouse Monoclonal Antibody) validated in IP, WB, IHC(P) to detect Estrogen Receptor α also known as ER, ER1, Estradiol Receptor, ER-alpha.
Western blot (human)

Immunoprecipitation (human)

Immunohistochemistry (mouse): faint staining

Immunohistochemistry (human): reactive on paraffin embedded sections after microwaving. *Some cytoplasmic staining may be seen.

Final working dilutions must be determined by end user.

Linkage

Replaces: 04-227

Physical form

Liquid

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to one year. Avoid repeated freeze-thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB447:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Intraprotomer masking of third variable loop (V3) epitopes by the first and second variable loops (V1V2) within the native HIV-1 envelope glycoprotein trimer.
Li Liu,Raffaello Cimbro,Paolo Lusso,Edward A Berger
Proceedings of the National Academy of Sciences of the USA null
Infectivity and neutralization of simian immunodeficiency virus with FLAG epitope insertion in gp120 variable loops.
Melissa E Laird,Ronald C Desrosiers
Journal of virology null
Sarah Kimmins et al.
Reproductive biology and endocrinology : RB&E, 1, 38-38 (2003-05-21)
We have shown previously that downregulation of intercaruncular stromal integrin alphavbeta3 in bovine endometrium on day 16 of the estrous cycle coincided with the antibody recognition of estrogen receptors (ER) in the luminal epithelium. In pregnancy, these changes were not
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
M Peressin,V Holl,S Schmidt,T Decoville,D Mirisky,A Lederle,M Delaporte,K Xu,A M Aubertin,C Moog
Journal of virology null
Estrogen-induced dimerization and activation of ER?-fused caspase-8: artificial reversal of the estrogenic hormone effect in carcinogenesis.
Zhi-Ning Zhao,Qiang Zhou,Jiu-Xu Bai,Bo Yan,Wei-Wei Qin,Tao Wang,Yi Li,An-Gang Yang,Lin-Tao Jia
Cancer Biology & Therapy null
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