MAB348B

Anti-Alzheimer Precursor Protein A4 Antibody, clone 22C11, Biotin Conj. | MAB348B

clone 22C11, from mouse, biotin conjugate

• Synonym(s): Amyloid beta A4 protein, ABPP, APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, CVAP, PreA4, Protease nexin-II, PN-II, N-APP, Soluble APP-alpha, S-APP-alpha, Soluble APP-beta, S-APP-beta, C99, Beta-amyloid protein 42, Beta
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• conjugate: biotin conjugate
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: 22C11, monoclonal
• species reactivity: rat, pig
• species reactivity (predicted by homology): porcine (based on 100% sequence homology), mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), human (based on 100% sequence homology), canine (based on 100% sequence homology)
• technique(s): immunocytochemistry: suitable; immunohistochemistry: suitable
• isotype: IgG1
• NCBI accession no.: NP_000475
• UniProt accession no.: P05067
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... APP(351)

Description

General description

Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer′s Disease. The principle component of this extracellular amyloid is beta A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins is currently an active area of research.

Specificity

This antibody recognizes Alzheimer Precursor Protein A4 at the N-temrinus.

Immunogen

Epitope: N-terminus

Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein

Application

Evaluated by Immunohistochemistry in adult rat brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in adult rat brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Quality

Evaluated by Immunocytochemistry in rat E18 primary cortex cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Alzheimer Precursor Protein A4 in rat E18 primary cortex cells.

Target description

Varies

Physical form

Protein A purified

Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Rat E18 primary cortex cells

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable