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Key Documents

Safety Information

MAB2499

Sigma-Aldrich

Anti-Fibrillin-1 Antibody, CT, clone 69

clone 69, Chemicon®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

69, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_000138.3

UniProt accession no.

P35555

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FBN1(2200)

Specificity

Monoclonal antibody MAB2499 recognizes human Fibrillin-1. Epitope mapping studies identify the binding site of this antibody to the C-terminal end of the molecule, between amino acid residues 2093 and 2871. The antibody is reactive with human, chicken, and bovine Fibrillin-1.

Immunogen

Epitope: C-terminus
Human Fibrillin-1

Application

Detect Fibrillin-1 using this Anti-Fibrillin-1 Antibody, C-terminus, clone 69 validated for use in ELISA, IP, WB & IC.
Immunoblotting

Immunofluorescence

Immunoprecipitation

ELISA

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
ECM Proteins

Physical form

Format: Purified
Purified immunoglobulin. Liquid at 1 mg/mL in 20 mM phosphate buffer, 250 mM NaCl, pH 7.6, containing 0.1% sodium azide.Note: Sodium azide is toxic. MSDS available upon request.

Storage and Stability

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB2499:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fibrillin-1 staining anomalies are associated with increased staining for TGF-beta and elastic fibre degradation; new clues to the pathogenesis of emphysema.
Mieke M J F Koenders,Ronnie G Wismans,Barry Starcher,Ben C J Hamel,Richard P N Dekhuijzen et al.
The Journal of Pathology null
Ko Tsutsui et al.
The Journal of biological chemistry, 285(7), 4870-4882 (2009-11-27)
ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs)-like (ADAMTSL) proteins, a subgroup of the ADAMTS superfamily, share several domains with ADAMTS proteinases, including thrombospondin type I repeats, a cysteine-rich domain, and an ADAMTS spacer, but lack a catalytic domain. We
Enrico Almici et al.
Frontiers in bioengineering and biotechnology, 10, 851825-851825 (2022-05-14)
Collagen VI-related dystrophies (COL6-RDs) are a group of rare congenital neuromuscular dystrophies that represent a continuum of overlapping clinical phenotypes that go from the milder Bethlem myopathy (BM) to the severe Ullrich congenital muscular dystrophy, for which there is no
Fibrillin-1 in human cartilage: developmental expression and formation of special banded fibers.
Keene, D R, et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 45, 1069-1082 (1997)
Expression of latent TGF-beta binding proteins and association with TGF-beta 1 and fibrillin-1 following arterial injury.
Sanjay Sinha, Anthony M Heagerty, C Adrian Shuttleworth, Cay M Kielty
Cardiovascular Research null
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