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Safety Information

MAB2250Z

Sigma-Aldrich

Anti-Integrin β1 Antibody, clone 21C8, azide free

clone 21C8, Chemicon®, from mouse

Synonym(s):

CD29, MAB2250

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

21C8, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

NCBI accession no.

NM_002292.3

UniProt accession no.

P55268

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)

Related Categories

Specificity

Reacts with the human integrin beta1 subunit. Specificity verified by preclearing of beta1in immunoprecipitation, flow cytometry on transfectant cells displaying human beta1 integrin, and reactivity with purified beta1. Recognizes distinct elements within the same epitope cluster bound by MAB2251.(Wilkins et al., 1996)

Immunogen

source is Jurkat T-leukemic cell line

Application

Immunoprecipitation

Immunohistochemistry on frozen sections

Flow cytometry

Stimulates adhesion of cells to extracellular matrix proteins (Wilkins et al., 1996)

Does not bind reduced beta1 integrin on Western blot

Optimal working dilutions must be determined by end user.
Research Category
Cell Structure
Research Sub Category
Integrins
This Anti-Integrin β1 Antibody, clone 21C8, azide free is validated for use in FC, IP, FUNC, IH for the detection of Integrin β1.

Physical form

Format: Purified
Purified immunoglobilin. Liquid in PBS, no preservatives.

Storage and Stability

Aliquot using sterile technique and maintain at 2-8°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB2250Z:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J A Wilkins et al.
The Journal of biological chemistry, 271(6), 3046-3051 (1996-02-09)
The beta1 integrins can be expressed on the surface of cells in a latent form, which is activated by a variety of stimuli. As an approach to examining the transition to an active receptor, a panel of stimulatory antibodies to

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