Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

MAB1820

Sigma-Aldrich

Anti-Scribble Antibody

clone 7C6.D10, Chemicon®, from mouse

Synonym(s):

Scrib, LAP4

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

7C6.D10, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

isotype

IgG1κ

GenBank accession no.

AAL38976

UniProt accession no.

Q14160

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SCRIB(23513)

General description

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Specificity

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Immunogen

Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Application

Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers

Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Quality

Routinely evaluated by Western blot on HeLa cell lysates.

Target description

220 kDa

Physical form

Format: Purified
Purified in PBS containing with 0.05% NaN3.

Storage and Stability

Maintain at 2-8°C for up to 1 year after date of receipt.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB1820:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

L E Dow et al.
Oncogene, 26(16), 2272-2282 (2006-10-18)
Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear. Mutations in Drosophila Scribble result in loss of polarity, overproliferation and 3D-tumourous overgrowth of epithelial cells. Using complementation studies in Drosophila
Mandy J Ludford-Menting et al.
Immunity, 22(6), 737-748 (2005-06-21)
T cell shape is dictated by the selective recruitment of molecules to different regions of the cell (polarity) and is integral to every aspect of T cell function, from migration to cytotoxicity. This study describes a mechanism for the regulation
Lukas E Dow et al.
Oncogene, 22(58), 9225-9230 (2003-12-19)
Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell polarity and have been identified as neoplastic tumour suppressor genes in Drosophila melanogaster. Here, we have used the Drosophila model system to provide the first
Patrick Humbert et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 25(6), 542-553 (2003-05-27)
Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service