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Safety Information

MAB1587

Sigma-Aldrich

Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2

clone 4D6.2, Chemicon®, from mouse

Synonym(s):

EAAT3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4D6.2, monoclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_004170.4

UniProt accession no.

P43005

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SLC1A1(6505)

Specificity

Glutamate Transporter EAAC1.

Based on protein sequence the antibody is expected to react with mouse, bovine and rabbit.

Immunogen

C-terminus peptide (KDKSDTISFTQTSQF) (Catalog Number AG372).

Application

Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 is an antibody against Glutamate Transporter for use in IH & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1-2 μg/mL

Immunohistochemistry: 1-2 μg/mL

Optimal working dilutions must be determined by end user.



EAAC1 is approximately 66-70kDa; the protein can form homomultimers during preparation as well, thus often times large 200-220kDa bands can also be seen.

Physical form

Format: Purified
Purified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C for up to six months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

MAB1587:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Decreased expression of the active subunit of the cystine/glutamate antiporter xCT is associated with loss of heterozygosity of 1p in oligodendroglial tumours WHO grade II.
Florian Stockhammer, Andreas von Deimling, Frank K H van Landeghem, Florian Stockhammer et al.
Histopathology null
Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1.
M Melone et al.
Molecular psychiatry, 8(1), 12-13 (2003-01-31)
M C Medrano et al.
British journal of pharmacology, 169(8), 1781-1794 (2013-05-04)
Excitatory amino acid transporters (EAATs) in the CNS contribute to the clearance of glutamate released during neurotransmission. The aim of this study was to explore the role of EAATs in the regulation of locus coeruleus (LC) neurons by glutamate. We
Han-Byeol Kim et al.
Cell death discovery, 6, 73-73 (2020-08-21)
Neonatal maternal separation (NMS), as an early-life stress (ELS), is a risk factor to develop emotional disorders. However, the exact mechanisms remain to be defined. In the present study, we investigated the mechanisms involved in developing emotional disorders caused by
Bárbara Coimbra et al.
Nature communications, 10(1), 4138-4138 (2019-09-14)
The laterodorsal tegmentum (LDT) is associated with reward considering that it modulates VTA neuronal activity, but recent anatomical evidence shows that the LDT also directly projects to nucleus accumbens (NAc). We show that the majority of LDT-NAc inputs are cholinergic
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