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IL038

Sigma-Aldrich

Interleukin-1β Protein, Recombinant human

The recombinant human Interleukin-1beta protein (or IL-1beta protein) is a potent immuno-modulator which mediates a wide range of immune & inflammatory responses including the activation of B & T-cells.

Synonym(s):

IL-1beta

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75

biological source

human

Quality Level

100

Assay

>98% (SDS-PAGE and HPLC)

specific activity

>1 x 10e9 U/mg

manufacturer/tradename

Chemicon®

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 ng/μg endotoxin (of human IL-1beta; 1EU/μg)

input

sample type hematopoietic stem cell(s)

NCBI accession no.

NM_000576.2

UniProt accession no.

P01584

shipped in

dry ice

General description

Interleukin-1beta (IL-1beta) is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T-cells. Human IL-1beta is a 17.3 kDa protein containing 153 amino acid residues.

Application

For most in vitro applications, human IL-1beta is fully biological activity in the concentration range of 0.1 to 10.0 ng/mL. Responding cells are (partial list): Leukocytes.

Physical form

Sterile filtered and lyophilized from 10 mM Tris, pH 8.2 with no preservatives.

Storage and Stability

The lyophilized human IL-1beta, though stable at room temperature, is best stored desiccated at -20°C. After a quick spin, reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can be diluted into other buffered solutions. Reconstituted human IL-1beta should be stored in undiluted aliquots at -20°C for up to six months.

Analysis Note

Specific Activity: Chemicon′s human IL-1beta is fully biologically active when compared to standards.The ED(50) as determined by the dose-dependent stimulation of the proliferation of murine D10S cells is <0.001 ng/mL

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

IL038:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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