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Safety Information

GF317

Sigma-Aldrich

TGF-β-III Protein, Human Recombinant Animal Free

TGF-β-III is one of three closely related mammalian members of the large TGF-β superfamily.Recombinant animal free human TGF-β-III is manufactured using all non-animal reagents.

Synonym(s):

Transforming Growth Factor Beta 3, TGF-Beta-3, TGF-Beta-III

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.75

recombinant

expressed in E. coli

Quality Level

100

Assay

>98% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1 EU/μg)

UniProt accession no.

P10600

shipped in

dry ice

Gene Information

human ... TGFB3(7043)

General description

Product Source: E. coli.
TGF-β-III (transforming growth factor beta III) is one of three closely related mammalian members of the large TGF-β superfamily. TGF-β-I, TGF-β-II and TGF-β-III are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial mesenchymal transition. TGF-β3 regulates molecules involved in cellular adhesion and extracellular matrix formation during the process of palate development. TGF-β3 also plays an essential role in controlling the development of lungs in mammals and controls wound healing by regulating the movements of epidermal and dermal cells in injured skin. Recombinant TGF-β-III is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Application

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

Quality

Determined by TGF-β-III’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expected ED50 is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

Physical form

Product is filtered through a 0.2 micron filter before lyophilization.
Recombinant animal free human TGF-β-III is manufactured using all non-animal reagents

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10-13 - German Storage Class 10 to 13

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

GF317:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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