EGLP-35BK

Glucagon Like Peptide-1 (Active) Space Saver (Bulk) ELISA

for protein sequence analysis, for protein analysis

• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.84

Properties

• grade: for protein analysis
• Quality Level: 100
• description: analytes available: Glucagon Like Peptide-1; 2-100 pg/mL (standard curve range)
• feature: accuracy 86.9 ± 5.2%
• species reactivity: rat, mouse, human
• technique(s): ELISA: suitable
• UniProt accession no.: P01275
• detection method: fluorometric

Description

General description

FUNCTION: SwissProt: P01275 # Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
SIZE: 180 amino acids; 20909 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.
PTM: Proglucagon is post-translationally processed in a tissue- specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
SIMILARITY: SwissProt: P01275 ## Belongs to the glucagon family.
MISCELLANEOUS: In the glucagon antagonist, His-53 and Phe-58 are missing. This antagonist has been successfully utilized to reduce glucose concentration in vivo."

Application

Overnight incubation at 4°C, followed by 2 hours 30 minutes at room temperature Sample volume <le> 100 ?l serum, plasma or tissue culture medium

Packaging

This product contains 10 GLP-1 (Active) ELISA kits.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Safety Information

• Pictograms: GHS08,GHS05,GHS07,GHS09
• Signal Word: Danger
• Hazard Statements: H315,H317,H318,H361fd,H373,H411
• Precautionary Statements: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Aquatic Chronic 2 - Eye Dam. 1 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Target Organs: Kidney,Liver,Blood
• Storage Class Code: 10 - Combustible liquids