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Key Documents

Safety Information

AB9906

Sigma-Aldrich

Anti-QKI-6 Antibody

serum, Chemicon®

Synonym(s):

Quaking Protein

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_006775.1
NM_206853.1
NM_206854.1
NM_206855.1

UniProt accession no.

Q96PU8

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... QKI(9444)

General description

QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing.

Specificity

QKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein.

Immunogen

Synthetic peptide from mouse QKI-6.

Application

Anti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience

RNA Binding Protein (RBP)

Physical form

Liquid.
Serum

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.

Analysis Note

Control
Positive Control: Glial cells, astrocytes and oligodendrocytes.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AB9906:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Daniel Larocque et al.
Nature neuroscience, 8(1), 27-33 (2004-11-30)
The quaking (Qk) locus expresses a family of RNA binding proteins, and the expression of several alternatively spliced isoforms coincides with the development of oligodendrocytes and the onset of myelination. Quaking viable (Qk(v)) mice harboring an autosomal recessive mutation in
Zhengyi Zhang et al.
Nature communications, 10(1), 4397-4397 (2019-09-29)
Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms of precursor. The preference of strand-selection is diverse during development and tissue formation, however, its pathological effect is still unknown.
Zhejia Zhang et al.
Oncology letters, 15(4), 5841-5848 (2018-03-21)
Thyroid cancer is the most frequently occurring type of endocrine tumor, with a rapidly increasing incidence rate. MicroRNA (miR)-574-5p is a candidate oncogene in various types of cancer. The present study identified that miR-574-5p affected the cell cycle distribution and
Xinyun Chen et al.
Nature communications, 12(1), 89-89 (2021-01-06)
The RNA-binding protein QKI belongs to the hnRNP K-homology domain protein family, a well-known regulator of pre-mRNA alternative splicing and is associated with several neurodevelopmental disorders. Qki is found highly expressed in developing and adult hearts. By employing the human

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