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Key Documents

Safety Information

AB5336P

Sigma-Aldrich

Anti-Synuclein α Antibody

Chemicon®, from sheep

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

sheep

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable (paraffin)

NCBI accession no.

NM_000345.2
NM_007308.1

UniProt accession no.

P37840

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)

Immunogen

Synthetic peptide corresponding amino acids 108-120 of human alpha synuclein.

Application

Anti-Synuclein Antibody, α is an antibody against Synuclein for use in IH(P).
Immunohistochemistry: 1:1,000 on frozen or paraffin sections.

Optimal working dilutions must be determined by the end user.

Linkage

Replaces: 04-1053

Physical form

Affinity purified immunoglobulin. Lyophilized. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue. Glycerol (1:1) can be added for additional stability.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Hazard Statements

H412

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 3

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Poisonous substance

JAN Code

AB5336P:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mohamed-Bilal Fares et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(7), E912-E921 (2016-02-04)
Lewy bodies (LBs) are intraneuronal inclusions consisting primarily of fibrillized human α-synuclein (hα-Syn) protein, which represent the major pathological hallmark of Parkinson's disease (PD). Although doubling hα-Syn expression provokes LB pathology in humans, hα-Syn overexpression does not trigger the formation
Aggresome-related biogenesis of Lewy bodies.
Kevin St P McNaught, P Shashidharan, Daniel P Perl, Peter Jenner, C Warren Olanow
The European Journal of Neuroscience null
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
Eslamboli, A; Romero-Ramos, M; Burger, C; Bjorklund, T; Muzyczka, N; Mandel, RJ; Baker et al.
Brain null
Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.
K A Conway, J C Rochet, R M Bieganski, P T Lansbury
Science (New York, N.Y.) null

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