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Safety Information

AB1891

Sigma-Aldrich

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop

Chemicon®, from rabbit

Synonym(s):

CX3CR1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_001337.3

UniProt accession no.

P49238

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... CX3CR1(1524)

General description

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.

Immunogen

Synthetic peptide from the extracellular loop of human CX3CR1.

Application

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop is an antibody against C-X-X-X-C Chemokine Receptor 1 for use in IH & WB.
Western blot: 1:500 (THP cell lysate can be used as positive control and an approximately 50 kDa band can be detected)

Immunohistochemistry in frozen sections

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AB1891:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Impact of chemokine receptor CX3CR1 in human renal allograft rejection.
Hoffmann U, Bergler T, Segerer S, Rummele P, Kruger B, Banas MC, Reinhold S, Banas B, Kramer BK
Transplant Immunology null
Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome.
Maria Victoria Ramos,Gabriela C Fernandez,Natasha Patey,Pablo Schierloh,Ramon Exeni et al.
Blood null
Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer.
Andre, F; Cabioglu, N; Assi, H; Sabourin, JC; Delaloge, S; Sahin, A; Broglio, K; Spano et al.
Annals of Oncology null
Expression of the fractalkine receptor (CX3CR1) in human kidney diseases.
Stephan Segerer, Erik Hughes, Kelly L Hudkins, Matthias Mack, Tracy Goodpaster, Charles E Alpers
Kidney International null
The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease.
Eardley, KS; Kubal, C; Zehnder, D; Quinkler, M; Lepenies, J; Savage, CO; Howie, AJ; Kaur et al.
Kidney International null
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