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Safety Information

AB1592P

Sigma-Aldrich

Anti-NMDAR2C Antibody, also recognizes NMDAR2A and 2B

Chemicon®, from rabbit

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

suitability

not suitable for immunohistochemistry

NCBI accession no.

NM_000835.3

UniProt accession no.

Q14957

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GRIN2C(2905)

Specificity

NMDAR2C. Immunolabels the 140 kD NMDAR2C subunit of the NMDA receptor. Also reacts with NMDAR2A and NMDAR2B by Western blot (180 kD).

Immunogen

Epitope: N-terminus
N-Terminal Fusion Protein of the NMDAR2C

Application

Detect NMDAR2C using this Anti-NMDAR2C Antibody, also recognizes NMDAR2A & 2B validated for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blotting 1:100-1:200

Immunoprecipitation: 3 μL will (under the appropriate conditions) quantitatively immunoprecipitate all NMDAR2C in 200 μg of rat cerebellum.

Not recommended for use in immunohistochemistry since the antibody also reacts with NMDAR2A and NMDAR2B.

Optimal working dilutions must be determined by the end user.

Physical form

Affinity purified immunoglobulin. Lyophilized from ammonium bicarbonate (5 mM), some residual salt may be present. Reconstitute with 50 μL of PBS.

Storage and Stability

Maintain lyophilized antibody at -20°C for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to six months.

Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

AB1592P:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spinal NMDA receptor phosphorylation correlates with the presence of neuropathic signs following peripheral nerve injury in the rat.
Camilla Ultenius, Bengt Linderoth, Bjorn A Meyerson, Johan Wallin
Neuroscience Letters null
Ionotropic glutamate receptors trigger microvesicle-mediated exocytosis of L-glutamate in rat pinealocytes.
S Yatsushiro, H Yamada, M Hayashi, A Yamamoto, Y Moriyama, S Yatsushiro, H Yamada et al.
Journal of Neurochemistry null
Josette S Lindahl et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 29(11), 2065-2073 (2004-05-13)
Phencyclidine (PCP) is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor subtype. It produces transient psychoses in normal individuals and exacerbates psychoses in schizophrenics. When administered to rodents, PCP elicits stereotypic behaviors including unrelenting head swaying, hyperlocomotion, and social
K K Yung
Neuroreport, 9(7), 1639-1644 (1998-06-19)
Immunocytochemical localization of metabotropic glutamate receptors (mGluRs) and ionotropic glutamate receptors (NMDA-type: NMDAR1 and NMDAR2A-C; AMPA-type: GluR1-4) was performed on sections of rat dorsal horn. Immunoreactivity for mGluR1 alpha was detected in laminae I-III of the dorsal horn, whilst mGluR2/3
H Wang et al.
Neuroscience, 188, 168-181 (2011-05-21)
Untimely activation of nicotinic acetylcholine receptors (nAChRs) by nicotine results in short- and long-term consequences on learning and behavior. In this study, the aim was to determine how prenatal nicotine exposure affects components of glutamatergic signaling in the hippocampus during
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