8.51095
PyOxim
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
Synonym(s):
PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
About This Item
Recommended Products
product name
PyOxim, Novabiochem®
Quality Level
product line
Novabiochem®
Assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
15-25°C
InChI
1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
InChI key
RDWDVLFMPFUBDV-PXMDEAMVSA-N
General description
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.
Features and Benefits
- Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
- Mediates coupling with low racemization or epimerization
- Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
- Excellent solubility in DMF and NMP
Analysis Note
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
PDSCL
Deleterious substance
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Articles
Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions.
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