Skip to Content
Merck
All Photos(2)

Key Documents

Safety Information

8.03649

Sigma-Aldrich

N,N′-Diisopropylcarbodiimide

≥99.0% (GC), for peptide synthesis

Synonym(s):

N,N′-Diisopropylcarbodiimide

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
Molecular Weight:
126.20
MDL number:
UNSPSC Code:
12352111
EC Index Number:
211-743-7
NACRES:
NA.22

product name

N,N′-Diisopropylcarbodiimide, for synthesis

Quality Level

Assay

≥99.0% (GC)

form

liquid

reaction suitability

reaction type: Coupling Reactions

bp

145-148 °C/1013 hPa

transition temp

flash point 33 °C

density

0.81 g/cm3 at 20 °C

application(s)

peptide synthesis

storage temp.

2-30°C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

General description

N,N′-Diisopropylcarbodiimide(DIC) is a liquid carbodiimide that contains the functional group RN=C=NR. It is soluble in most organic solvents. DIC is used as a coupling agent in peptide synthesis.

Application

  • Synthesis, structure and reactivity study of magnesium amidinato complexes derived from carbodiimides and N, N′-bis (2, 6-diisopropylphenyl)-1, 4-diaza …: This study involved the preparation of magnesium amidinato complexes using N,N′-Diisopropylcarbodiimide, exploring their structural and reactive properties in various chemical transformations (S Anga, J Bhattacharjee, A Harinath, TK Panda, 2015).

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.813 - 0.815
Identity (IR): passes test

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

91.4 °F

Flash Point(C)

33 °C


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Flammable liquids
Type 2 petroleums
Hazardous rank III
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A solvent-reagent selection guide for Steglich-type esterification of carboxylic acids
Jordan A, et al.
Green Chemistry, 23(17), 6405-6413 (2021)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service