8.03068
N,N-Dimethylformamide dimethyl acetal
for synthesis
Synonym(s):
N,N-Dimethylformamide dimethyl acetal, N,N-Dimethyldimethoxymethylamine, DMF-DMA
About This Item
Recommended Products
Quality Level
form
liquid
autoignition temp.
155 °C
potency
>5000 mg/kg LD50, oral (Rat)
expl. lim.
1.3-17.7 % (v/v)
pH
7 ( in H2O)
mp
-85 °C
transition temp
flash point 6 °C
density
0.895 g/cm3 at 20 °C
storage temp.
2-30°C
InChI
1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3/p+1
InChI key
ZSXGLVDWWRXATF-UHFFFAOYSA-O
General description
- As a methylating agent, DMF-DMA has been used in the synthesis of methyl esters from acids, methyl ethers, and thioethers from phenols and aromatic thiols.
- DMF-DMA has been used as a formulating agent to synthesize enamines from active methylenes and active methyl groups, and amidines from amines and amides or thioamide.
- It is also possible to produce heterocyclic compounds using DMF-DMA by cyclizing two functional groups.
Application
- In the synthesis of spirooxindole and pyrazole scaffolds via [3+2] cycloaddition reaction of electron-deficient olefins-based pyrazole motif.
- As a reagent in the synthesis of3-acetyl-4-arylquinoline-based enaminones under microwave irradiation.
Analysis Note
Density (d 20 °C/ 4 °C): 0.893 - 0.897
Identity (IR): passes test
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Eye Dam. 1 - Flam. Liq. 2 - Repr. 1B - Skin Sens. 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
42.8 °F
Flash Point(C)
6 °C
Regulatory Listings
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FSL
Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid
ISHL Indicated Name
Substances Subject to be Indicated Names
ISHL Notified Names
Substances Subject to be Notified Names
Certificates of Analysis (COA)
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